Atovaquone/Proguanil Therapy forPlasmodium falciparumandPlasmodium vivaxMalaria in Indonesians Who Lack Clinical Immunity

Atovaquone/proguanil therapy for Plasmodium falciparum and Plasmodium vivax malaria in Indonesians who lack clinical immunity.

Thirty-eight of 295 subjects participating in a randomized, double-blind, placebo-controlled trial of the efficacy of daily administration of atovaquone/proguanil for malaria prevention developed malaria at some time during the 20-week prophylaxis period. These subjects (3 atovaquone/proguanil recipients and 35 placebo recipients) were treated with 4 tablets of atovaquone/proguanil per day for ...

Dysregulation of innate immunity in ulcerative colitis patients who fail anti-tumor necrosis factor therapy

AIM To study the innate immune function in ulcerative colitis (UC) patients who fail to respond to anti-tumor necrosis factor (TNF) therapy. METHODS Effects of anti-TNF therapy, inflammation and medications on innate immune function were assessed by measuring peripheral blood mononuclear cell (PBMC) cytokine expression from 18 inflammatory bowel disease patients pre- and 3 mo post-anti-TNF th...

Antigen-Specific Immunity in Lack of Effective MUC1 Tumor

Prevalence and clinical profile of diabetes mellitus in productive aged urban Indonesians

AIMS/INTRODUCTION To estimate the prevalence and clinical profile of diabetes mellitus in productive aged urban Indonesians based on the National Basic Health Research 2007. MATERIALS AND METHODS The statistical analyses of a cross-sectional survey included the data of 15,332 adults, aged 18-55 years, living in an urban area. Blood glucose was measured by an automatic clinical chemistry analy...

Analysis of immunity to febrile malaria in children that distinguishes immunity from lack of exposure.

In studies of immunity to malaria, the absence of febrile malaria is commonly considered evidence of "protection." However, apparent "protection" may be due to a lack of exposure to infective mosquito bites or due to immunity. We studied a cohort that was given curative antimalarials before monitoring began and documented newly acquired asymptomatic parasitemia and febrile malaria episodes duri...